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WellMe Collagen Refresh Reviews and Complaints This diverse array of sources ensures that the body has immediate access to a wide spectrum of amino acids that serve as the raw material for tissue repair. For instance, Vitamin C is included as an indispensable cofactor; without it, the body is biochemically incapable of forming or storing collagen fibers. Copper is another critical inclusion, as it activates the enzyme prolyl hydroxylase, which essentially acts as the glue that links collagen fibers together to create a strong, stable network. WellMe Collagen Refresh also features Vitamin E, a powerful antioxidant that shields delicate collagen fibers from the destructive effects of free radicals and oxidative trauma, ensuring that the collagen produced remains functional for a longer period.